WHAT YOU NEED TO KNOW
Features or Compounds? A Data Reduction Strategy for Untargeted Metabolomics to Generate Meaningful Data
Untargeted metabolomics describes an unbiased approach that globally analyzes the metabolome in any given sample. Comprehensive metabolome coverage is obtained using analytical techniques such as liquid chromatography – mass spectrometry (LC-MS) by collecting all measurements indiscriminately. READ MORE
Compounding Insights for Small Molecule Research
The challenge for small-molecule analysis is to efficiently extract high-confidence understanding from this data, particularly determining and identifying components of interest in chemically complex samples. When performing small molecule research, scientists often have to manually process and integrate their data using multiple third party applications or rely on third party experts. READ MORE
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Journey from Features to Compound ID in Metabolomics
HRAM LC-MS is a powerful tool for untargeted metabolomics analysis and detects all ionic species present in analyzed samples generating an exhaustive results list of molecular features. Taking all of these experimental artifacts into consideration during data processing enables a proactive approach to eliminating redundancies and unrelated ions. Learn More. |
Finding Targets in Cancer’s Metabolic Quirks
Almost 100 years ago, German biochemist Otto Heinrich Warburg noticed that cancer cells tend to have a high rate of glycolysis compared to normal tissues. This phenomenon, which occurs in cancer cells along with increased glucose uptake and fermentation of glucose to lactate, is known as the Warburg effect. Present-day explanations for the Warburg effect remain unsettled. READ MORE
Solving the Puzzle of Cell Culture Optimization
Biologics have transformed the therapeutic landscape. Twenty years ago, the pharmaceutical industry could hardly have envisioned the growth and broad impact that biologics would have today. “Now, they’re not just part of the therapeutic landscape—they’ve become key defining components of most pharmaceutical pipelines.” READ MORE
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